In situ structure and organization of the influenza C virus surface glycoprotein

Influenza C virus contains a single surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities.Here, the authors Optimiser apply electron cryotomography of whole virus together with subtomogram averaging to determine the HEF structure Foam Cleanser and lattice organisation on the viral membrane and they discuss mechanistic implications for virus budding and membrane fusion.